慢性鼻-鼻窦炎患者鼻黏膜组织Eotaxin、SOCS3表达与术后复发的关系

Relationship between the expression of eotaxin and SOCS3 in nasal mucosa and postoperative recurrence in patients with chronic rhinosinusitis

摘要:

目的 观察慢性鼻-鼻窦炎(CRS)患者鼻黏膜组织嗜酸粒细胞趋化因子(Eotaxin)、人细胞因子信号转导抑制因子3(SOCS3)表达与术后复发的关系。方法 选取2020年5月至2023年5月于庆阳市人民医院进行治疗的CRS患者120例为研究对象，患者均行鼻内镜手术，术后随访1年评估复发情况。根据是否复发将患者分为复发组(n=32)与未复发组(n=88),术后复发的危险因素使用多因素Logistic回归分析，并采用受试者工作特征曲线(ROC)分析Eotaxin与SOCS3表达水平对患者术后复发的评估价值。结果 两组吸烟史、伴鼻息肉、哮喘、有过敏因素、术后感染患者比例、Eotaxin与SOCS3表达水平比较，差异均有统计学意义(P<0.05)。复发组中，伴鼻息肉与不伴鼻息肉患者的Eotaxin、SOCS3表达水平比较，差异无统计学意义(P>0.05)。多因素Logistic回归分析显示，CRS伴鼻息肉、过敏因素、术后感染、Eotaxin与SOCS3表达水平均是影响术后复发的危险因素(P<0.05)。ROC曲线分析显示，Eotaxin、SOCS3二者联合检测ROC曲线下面积(AUC)为0.900,灵敏度为84.37%,特异度为86.36%。结论 CRS伴鼻息肉、过敏因素、术后感染、Eotaxin与SOCS3表达水平均是影响CRS患者术后复发的危险因素，Eotaxin与SOCS3联合检测对术后复发预测效能较高。

Abstract:

Objective ToinvestigatetherelationshipbetweentheexpressionofEotaxinandsuppressorofcytokine signaling3(SOCS3)innasalmucosatissuesandpostoperativerecurrenceinpatientswithchronicrhinosinusitis (CRS). Methods Atotalof126patientswithCRStreatedinQingyangPeople'sHospitalfrom May2020toMay2023wereselected, allofwhomunderwentnasalendoscopicsurgery.Thepatientswerefollowedupfor1yearaftersurgerytoevaluatewhether recurrenceoccurred.Thepatientsweredividedintoarecurrencegroup(n=32)andanon-recurrencegroup(n=88)basedon whethertherewasarecurrence.Multivariatelogisticregressionanalysiswasusedtoidentifytheriskfactorsforpostoperative recurrenceinCRSpatients.Receiveroperatingcharacteristic(ROC)curveswereplottedtoevaluatethevalueofEotaxinand SOCS3expressionlevelsinpredictingpostoperativerecurrenceinCRSpatients.Results Thereweresignificantdifferencesin theproportionofpatientswithsmokinghistory,nasalpolyps,asthma,allergicfactors,andpostoperativeinfections,aswell asintheexpressionlevelsofEotaxinandSOCS3betweenthetwogroups(P<0.05).Therewasnostatisticallysignificant differenceintheexpressionlevelsofEotaxinandSOCS3betweenpatientswithandwithoutnasalpolypsintherecurrence group (P >0.05). Multivariatelogisticregression analysisshowedthat CRS with nasalpolyps,allergicfactors, postoperativeinfections,andtheexpressionlevelsofEotaxinandSOCS3wereriskfactorsforpostoperativerecurrencein CRSpatients(P<0.05).ROCcurveanalysisshowedthatthecombineddetectionofEotaxinandSOCS3resultedinanarea undertheROCcurve(AUC)of0.900,withasensitivityof84.37% andaspecificityof86.36%.Conclusion CRSwith nasalpolyps,allergicfactors,postoperativeinfections,andtheexpressionlevelsofEotaxinandSOCS3areriskfactorsfor postoperativerecurrenceinpatientswithCRS.ThecombineddetectionofEotaxinandSOCS3expressionlevelshashigh predictiveefficacyforpostoperativerecurrenceofCRS.